The MeMBrane project aims to improve the tolerance of microbes to the stresses encountered during industrial bioprocesses by modifying the cell membranes. Working with yeast and Propionibacterium, the project will use synthetic biology to progress and exploit our understanding of the toxicity challenges to improve efficiency and product yield of engineered cell-based factories. Membrane composition will be modelled in silico and tested in in vitro systems. Strains successfully validated at lab scale will be tested at pilot scale by our industrial partners, Lallemand and Pakmaya.
MeMBrane is a 3 year project funded by ERA CoBioTech with a multidisciplinary consortium of academics, industrial partners and subcontractors from across Europe. The project is led by Dr Alan Goddard from Aston University.